West Nile Virus Infection in Sheep

被引：16

作者：

Rimoldi, G. ^{[1
]}

Mete, A. ^{[1
]}

Adaska, J. M. ^{[1
]}

Anderson, M. L. ^{[1
]}

Symmes, K. P. ^{[2
]}

Diab, S. ^{[1
]}

机构：

[1] Univ Calif Davis, Calif Anim Hlth & Food Safety Lab Syst, 18830 Rd 112, Tulare, CA 93274 USA

[2] Univ Calif Davis, Davis Arbovirus Res & Training, Dept Pathol Microbiol & Immunol, Sch Vet Med, 18830 Rd 112, Tulare, CA 93274 USA

来源：

VETERINARY PATHOLOGY | 2017年 / 54卷 / 01期

关键词：

brain; encephalitis; encephalomyelitis; nervous system disease; phylogeny; sheep; West Nile virus; CALIFORNIA; HORSES;

D O I：

10.1177/0300985816653796

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

West Nile virus (WNV) infection has been detected in many species of birds and mammals, but scant information is available about the disease in small ruminants. West Nile virus was diagnosed in 6 sheep with neurological signs and encephalitis, in California between 2002 and 2014. All sheep had severe lymphoplasmacytic meningoencephalitis. Lymphoplasmacytic myelitis was also detected in 2 sheep where the spinal cord was examined. Brain tissue was positive for WNV detected by polymerase chain reaction in 6 of 6 sheep and by immunohistochemistry (IHC) in 5 of 6 sheep. Viral antigen was not detected by IHC in extraneural tissues in the 3 sheep examined. West Nile virus RNA was sequenced from 2 of 6 sheep, and each one clusters closely with WNV isolated from mosquito pools from nearby locations at similar times. West Nile virus was the most common cause of viral encephalitis in sheep diagnosed at this laboratory between 2002 and 2014, accounting for 6 of 9 sheep.

引用

页码：155 / 158

页数：4

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