Rhodium(III)-Catalyzed Intermolecular Direct Amidation of Aldehyde C H Bonds with N-Chloroamines at Room Temperature

被引：53

作者：

Zhou, Bing ^{[1
]}

Du, Juanjuan ^{[1
]}

Yang, Yaxi ^{[1
]}

Li, Yuanchao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 12期

关键词：

OXIDATIVE ORTHO-ACYLATION; O-METHYL OXIMES; AMIDE-BOND; EFFICIENT SYNTHESIS; ALKYL AZIDES; ACTIVATION; ARYL; RH; HYDROACYLATION; FUNCTIONALIZATION;

D O I：

10.1021/ol400921r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(III)-catalyzed direct aldehyde C-H amidation from aldehydes and N-chloroamines, prepared in situ from amines, has been developed via C-H bond activation under very mild reaction conditions. A variety of primary and secondary amines were used to afford the corresponding amides in moderate to excellent yields.

引用

页码：2934 / 2937

页数：4

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