Is it possible to increase the specificity for the performance of prostatic biopsy in patients with PSA between 4 and 10 ng/ml and free/total PSA ratio < 20%?

被引：0
|
作者：
Angel Arrabal-Polol, Miguel [1 ]
Dominguez-Amillo, Alejandro [2 ,3 ]
del Carmen Cano-Garcia, Maria [1 ]
Arrabal-Martin, Miguel [2 ,3 ]
Lopez-Carmona Pintado, Fernando [2 ,3 ]
Cozar Olmo, Jose Manuel [2 ,3 ]
机构：
[1] Hosp La Inmaculada, UGC Urol, Huercal Overa, Almeria, Spain
[2] Complejo Hosp Univ Granada, UGC Urol, Granada, Spain
[3] Inst IBS Granada, Granada, Spain
来源：
ARCHIVOS ESPANOLES DE UROLOGIA | 2015年 / 68卷 / 07期
关键词：
Testosterone; Prostate biopsy; Prostate cancer; Specificity; PSA; TOTAL TESTOSTERONE; CANCER DETECTION; ANTIGEN; PREDICTOR; MEN;
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
OBJECTIVE: To investigate the manner to increase specificity in the decision-making process for the performance of prostate biopsy. METHODS: We include in this study men with PSA between 4 and 10 ng/ml and free/total PSA < 20%, candidates for prostate biopsy Patients receiving 5 alpha reductase inhibitors or with previous biopsies were excluded. Analyzed variables: total PSA, total testosterone, free and bioavailable testosterone, FSH, LH, SHBG, 17 hydroxyprogesterone, Androstenedione, prostatic volume measured by transrectal ultrasound, total testosterone/PSA, testosterone/free PSA, bio available testosterone/PSA and PSA density, total testosterone/prostate volume, free testosterone/prostate volume and bioavaibble testosterone/prostate volume. RESULTS: A total 109 patients have been included, divided into 2 groups according to the results of the biopsy Significant differences were observed in prostatic volume (Group 1: 36.6cc and Group 2: 52.8 cc; p=0.04), PSA density (Group 1: 0.24 Group 2: 0.17; p=0.002), total testosterone/prostate volume (Group 1: 0.15 and Group 2: 0.10; p=0.02) free testosterone/ prostate volume (Group 1: 0.002 Group 2: 0.001; 13=0.01) and bioavailable testosterone/prostate volume (Group 1: 0.06 Group 2: 0.04; p=0.007). CONCLUSION: The decision for a prostate biopsy on patients with a PSA between 4-10 ng/ml with free/total ratio 20% continues to be an issue, however, we can optimize decision 'using other parameters such as prostate volume, PSA density and bioavailable testosterone/prostate volume.
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页码：595 / 601
页数：7
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