Absolute stereochemistry of cicutoxin and related toxic polyacetylenic alcohols from Cicuta virosa

被引：29
|
作者：
Ohta, T [1 ]
Uwai, K
Kikuchi, R
Nozoe, S
Oshima, Y
Sasaki, K
Yoshizaki, F
机构：
[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9200934, Japan
[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9800856, Japan
[3] Tohoku Coll Pharm, Sendai, Miyagi 9810905, Japan
来源：
TETRAHEDRON | 1999年 / 55卷 / 41期
关键词：
polyacetylenic alcohols; optical properties; stereochemistry;
D O I：
10.1016/S0040-4020(99)00706-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The absolute stereostructures of cicutoxin (1) and related toxic polyacetylenic alcohols, isocicutoxin (2), and virols A (3) and C (4), from Cicuta virosa were determined on the basis of spectroscopic analysis. The CD exciton chirality method was successfully applied to 4-methoxybenzoates of dyne-conjugated polyenyl alcohol systems. Fatal doses of these compounds on mice are also reported. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：12087 / 12098
页数：12
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