Construction of 2-Substituted-3-Functionalized Benzofurans via Intramolecular Heck Coupling: Application to Enantioselective Total Synthesis of Daphnodorin B

被引：69

作者：

Yuan, Hu ^{[1
,2
]}

Bi, Kai-Jian ^{[1
]}

Li, Bo ^{[1
]}

Yue, Rong-Cai ^{[1
]}

Ye, Ji ^{[1
]}

Shen, Yun-Heng ^{[1
]}

Shan, Lei ^{[1
]}

Jin, Hui-Zi ^{[2
]}

Sun, Qing-Yan ^{[3
]}

Zhang, Wei-Dong ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[3] Second Mil Med Univ, Sch Pharm, Dept Organ Chem, Shanghai 200433, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 18期

关键词：

FUNCTIONALIZED BENZOFURANS; CARBONYLATIVE ANNULATION; COMBINATORIAL SYNTHESIS; EFFICIENT; FLAVANS; ACYLPHENYLCARBONATES; 12-LIPOXYGENASE; CONSTITUENTS; ACYLPHENOLS; CYCLIZATION;

D O I：

10.1021/ol4021095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach was developed for the synthesis of 2-substituted-3-functionalized benzofurans, using an intramolecular Heck reaction which was further applied in the first enantioselective total synthesis of Daphnodorin B.

引用

页码：4742 / 4745

页数：4

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