Vitiligo following a combined liver-kidney transplant

被引:4
|
作者
Bradley, Victoria [1 ]
Kemp, Elizabeth Helen [2 ]
Dickinson, Claire [1 ]
Key, Tim [3 ]
Gibbs, Paul [4 ]
Clatworthy, Menna R. [5 ]
机构
[1] Univ Sheffield, Cambridge Sch Clin Med, Sheffield, S Yorkshire, England
[2] Univ Sheffield, Sch Med & Biomed Sci, Sheffield, S Yorkshire, England
[3] Addenbrookes Hosp, Tissue Typing Lab, Cambridge, England
[4] Univ Cambridge, Dept Surg, Cambridge, England
[5] Univ Cambridge, Dept Med, Cambridge Inst Med Res, Div Renal Med, Cambridge CB2 2QQ, England
基金
英国惠康基金;
关键词
RESPONSES;
D O I
10.1093/ndt/gfn661
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
We report an Afro-Caribbean male who developed vitiligo 10 days following a combined liver-kidney transplant from a Caucasian donor. Neither the donor nor the recipient had any previous history of vitiligo, nor of autoimmunity. The depigmentation gradually resolved by 8 weeks post-transplant with topical corticosteroids and standard maintenance immunosuppression. We propose that the skin depigmentation occurred due to the destruction of melanocytes by donor-derived alloreactive cytotoxic T-lymphocytes or antibody transferred during transplantation. Although vitiligo has been described in patients receiving allogeneic bone marrow transplantation for haematological malignancy, there are no previous reports of vitiligo post-solid organ transplantation.
引用
收藏
页码:686 / 688
页数:3
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