The proteome of clear cell ovarian carcinoma

被引：8

作者：

Ji, Jennifer X. ^{[1
]}

Cochrane, Dawn R. ^{[2
]}

Negri, Gian Luca ^{[3
]}

Colborne, Shane ^{[3
]}

Miko, Sandra E. Spencer ^{[3
]}

Hoang, Lynn N. ^{[1
]}

Farnell, David ^{[1
]}

Tessier-Cloutier, Basile ^{[1
]}

Huvila, Jutta ^{[2
,4
]}

Thompson, Emily ^{[1
]}

Leung, Samuel ^{[5
]}

Chiu, Derek ^{[5
]}

Chow, Christine ^{[5
]}

Ta, Monica ^{[5
]}

Kobel, Martin ^{[6
]}

Feil, Lucas ^{[7
]}

Anglesio, Michael ^{[7
]}

Goode, Ellen L. ^{[8
]}

Bolton, Kelly ^{[9
]}

Morin, Gregg B. ^{[3
,10
]}

Huntsman, David G. ^{[1
,2
,7
]}

机构：

[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[2] BC Canc Agcy, Dept Mol Oncol, Vancouver, BC, Canada

[3] Univ British Columbia, Canadas Michael Smith Genome Sci Ctr, BC Canc Res Inst, Vancouver, BC, Canada

[4] Univ Turku, Dept Biomed, Turku, Finland

[5] Genet Pathol Evaluat Ctr, Vancouver, BC, Canada

[6] Univ Calgary, Pathol & Lab Med, Calgary, AB, Canada

[7] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC, Canada

[8] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[9] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[10] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada

来源：

JOURNAL OF PATHOLOGY | 2022年 / 258卷 / 04期

基金：

加拿大健康研究院;

关键词：

clear cell ovarian carcinoma; proteomics; epithelial ovarian carcinoma; high-grade serous ovarian carcinoma; endometrioid ovarian carcinoma; immunohistochemistry; CANCER INCIDENCE; GENE-EXPRESSION; CLASS DISCOVERY; RISK-FACTORS; ENDOMETRIOSIS; MUTATIONS; PIK3CA; EVENT;

D O I：

10.1002/path.6006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late-stage CCOC is not responsive to gold-standard chemotherapy and results in suboptimal outcomes for patients. In-depth molecular insight is urgently needed to stratify the disease and drive therapeutic development. We conducted global proteomics for 192 cases of CCOC and compared these with other epithelial ovarian carcinoma subtypes. Our results showed distinct proteomic differences in CCOC compared with other epithelial ovarian cancer subtypes including alterations in lipid and purine metabolism pathways. Furthermore, we report potential clinically significant proteomic subgroups within CCOC, suggesting the biologic plausibility of stratified treatment for this cancer. Taken together, our results provide a comprehensive understanding of the CCOC proteomic landscape to facilitate future understanding and research of this disease. (c) 2022 The Pathological Society of Great Britain and Ireland.

引用

页码：325 / 338

页数：14

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