Moderators of the effect of psychosocial interventions on fatigue in women with breast cancer and men with prostate cancer: Individual patient data meta-analyses

被引：8

作者：

Abrahams, Harriet J. G. ^{[1
]}

Knoop, Hans ^{[1
]}

Schreurs, Maartje ^{[2
]}

Aaronson, Neil K. ^{[3
]}

Jacobsen, Paul B. ^{[4
]}

Newton, Robert U. ^{[5
]}

Courneya, Kerry S. ^{[6
]}

Aitken, Joanne F. ^{[7
,8
,9
,10
]}

Arving, Cecilia ^{[11
]}

Brandberg, Yvonne ^{[12
]}

Chambers, Suzanne K. ^{[7
,13
,14
,15
]}

Gielissen, Marieke F. M. ^{[16
]}

Glimelius, Bengt ^{[17
]}

Goedendorp, Martine M. ^{[18
,19
]}

Graves, Kristi D. ^{[20
]}

Heiney, Sue P. ^{[21
]}

Horne, Rob ^{[22
]}

Hunter, Myra S. ^{[23
]}

Johansson, Birgitta ^{[17
]}

Northouse, Laurel L. ^{[24
]}

Oldenburg, Hester S. A. ^{[25
]}

Prins, Judith B. ^{[26
]}

Savard, Josee ^{[27
,28
]}

van Beurden, Marc ^{[29
]}

van den Berg, Sanne W. ^{[30
]}

Verdonck-de Leeuw, Irma M. ^{[31
,32
]}

Buffart, Laurien M. ^{[2
,5
,33
,34
]}

机构：

[1] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Med Psychol, Amsterdam UMC, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[3] Netherlands Canc Inst, Div Psychosocial Res & Epidmiol, Amsterdam, Netherlands

[4] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[5] Edith Cowan Univ, Exercise Med Res Inst, Joondalup, WA, Australia

[6] Univ Alberta, Fac Kinesiol Sport & Recreat, Edmonton, AB, Canada

[7] Griffith Univ, Menzies Hlth Inst Queensland, Southport, Qld, Australia

[8] Canc Council Queensland, Brisbane, Qld, Australia

[9] Univ Southern Queensland, Inst Resilient Reg, Brisbane, Qld, Australia

[10] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia

[11] Uppsala Univ, Dep Publ Hlth & Caring Sci, Uppsala, Sweden

[12] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden

[13] Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia

[14] Univ Southern Queensland, Inst Resilient Reg, Springfield, Qld, Australia

[15] Edith Cowan Univ, Hlth & Wellness Inst, Perth, WA, Australia

[16] Acad Het Dorp Siza, Arnhem, Netherlands

[17] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden

[18] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam UMC, Amsterdam, Netherlands

[19] Univ Med Ctr Groningen, Univ Groningen, Dept Hlth Psychol, Groningen, Netherlands

[20] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA

[21] Univ South Carolina, Coll Nursing, Columbia, SC 29208 USA

[22] UCL, Sch Pharm, London, England

[23] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[24] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA

[25] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg Oncol, Amsterdam, Netherlands

[26] Radboud Univ Nijmegen, Inst Hlth Sci, Dept Med Psychol, Med Ctr, Nijmegen, Netherlands

[27] Univ Laval, Sch Psychol, Quebec City, PQ, Canada

[28] Laval Univ, Canc Res Ctr, Quebec City, PQ, Canada

[29] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Gynecol, Amsterdam, Netherlands

[30] Radboud Univ Nijmegen, Behav Sci Inst, Nijmegen, Netherlands

[31] Vrije Univ Amsterdam, Dept Otolaryngol Head & Neck Surg, Canc Ctr Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

[32] Vrije Univ Amsterdam, Dept Clin Neuro & Dev Psychol, Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Amsterdam, Netherlands

[33] Vrije Univ Amsterdam, Amsterdam UMC, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands

[34] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, Radboud Inst Hlth Sci, Nijmegen, Netherlands

来源：

PSYCHO-ONCOLOGY | 2020年 / 29卷 / 11期

关键词：

breast cancer; cancer; fatigue; individual patient data meta-analysis; moderators; oncology; prostate cancer; psycho-oncology; psychosocial interventions; QUALITY-OF-LIFE; COGNITIVE-BEHAVIOR THERAPY; RANDOMIZED CLINICAL-TRIAL; MENOPAUSAL SYMPTOMS; FAMILY INTERVENTION; PHYSICAL FUNCTION; EXERCISE; EFFICACY; DEPRESSION; MANAGEMENT;

D O I：

10.1002/pon.5522

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective Psychosocial interventions can reduce cancer-related fatigue effectively. However, it is still unclear if intervention effects differ across subgroups of patients. These meta-analyses aimed at evaluating moderator effects of (a) sociodemographic characteristics, (b) clinical characteristics, (c) baseline levels of fatigue and other symptoms, and (d) intervention-related characteristics on the effect of psychosocial interventions on cancer-related fatigue in patients with non-metastatic breast and prostate cancer. Methods Data were retrieved from the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) consortium. Potential moderators were studied with meta-analyses of pooled individual patient data from 14 randomized controlled trials through linear mixed-effects models with interaction tests. The analyses were conducted separately in patients with breast (n = 1091) and prostate cancer (n = 1008). Results Statistically significant, small overall effects of psychosocial interventions on fatigue were found (breast cancer: beta = -0.19 [95% confidence interval (95%CI) = -0.30; -0.08]; prostate cancer: beta = -0.11 [95%CI = -0.21; -0.00]). In both patient groups, intervention effects did not differ significantly by sociodemographic or clinical characteristics, nor by baseline levels of fatigue or pain. For intervention-related moderators (only tested among women with breast cancer), statistically significant larger effects were found for cognitive behavioral therapy as intervention strategy (beta = -0.27 [95%CI = -0.40; -0.15]), fatigue-specific interventions (beta = -0.48 [95%CI = -0.79; -0.18]), and interventions that only targeted patients with clinically relevant fatigue (beta = -0.85 [95%CI = -1.40; -0.30]). Conclusions Our findings did not provide evidence that any selected demographic or clinical characteristic, or baseline levels of fatigue or pain, moderated effects of psychosocial interventions on fatigue. A specific focus on decreasing fatigue seems beneficial for patients with breast cancer with clinically relevant fatigue.

引用

页码：1772 / 1785

页数：14

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