Ionic liquids as new media for electrophilic trifluoromethylation reactions

被引：9

作者：

Pegot, Bruce ^{[1
]}

Mace, Yohan ^{[1
]}

Urban, Celine ^{[1
]}

Diter, Patrick ^{[1
]}

Blazejewski, Jean-Claude ^{[1
]}

Magnier, Emmanuel ^{[1
]}

机构：

[1] Univ Versailles, UMR CNRS 8180, ILV, F-78035 Versailles, France

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 134卷

关键词：

Fluorine; Sulfur heterocycles; Electrophilic trifluoromethylation; Ionic liquids; AGENTS; S-(TRIFLUOROMETHYL)DIBENZOTHIOPHENIUM; REAGENT; SALTS;

D O I：

10.1016/j.jfluchem.2011.03.004

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The electrophilic trifluoromethylation of aniline with a range of trifluoromethyl sulfonium salts has been studied in ionic liquids as solvent. The best ionic liquid for this reaction was identified after extensive scrutiny of the influence of the cation's nature (imidazolium or pyridinium salts), the effect of the alkyl side chain length of the cation, as well as that of the counter anion. Recycling experiments have demonstrated that the purification protocol was greatly simplified over conventional reactions performed in DMF and that the solvent could be reused five times without significant loss of activity. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：156 / 159

页数：4

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