Remodeling of Tumor Immune Microenvironment by Oncolytic Viruses

被引：23

作者：

Zhang, Bin

Wang, Xilei

Cheng, Ping ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 10卷

基金：

中国国家自然科学基金;

关键词：

oncolytic virus; tumor immune microenvironment; immune cells; cytokines; immune checkpoints; DENDRITIC CELLS; TRAFFICKING; METASTASIS;

D O I：

10.3389/fonc.2020.561372

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncolytic viruses (OVs) are potential antitumor agents with unique therapeutic mechanisms. They possess the ability of direct oncolysis and the induction of antitumor immunity. OV can be genetically engineered to potentiate antitumor efficacy by remodeling the tumor immune microenvironment. The present mini review mainly describes the effect of OVs on remodeling of the tumor immune microenvironment and explores the mechanism of regulation of the host immune system and the promotion of the immune cells to destroy carcinoma cells by OVs. Furthermore, this article focuses on the utilization of OVs as vectors for the delivery of immunomodulatory cytokines or antibodies.

引用

页数：9

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