Failure of pulse high-dose dexamethasone in chronic idiopathic immune thrombocytopenia

被引:0
|
作者
Warner, M
Wasi, P
Couban, S
Hayward, C
Warkentin, T
Kelton, JG
机构
[1] MCMASTER UNIV,MED CTR,DEPT PATHOL,HAMILTON,ON L8N 3Z5,CANADA
[2] CANADIAN RED CROSS SOC,HAMILTON,ON,CANADA
关键词
platelet; dexamethasone; thrombocytopenia;
D O I
10.1002/(SICI)1096-8652(199704)54:4<267::AID-AJH1>3.3.CO;2-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Idiopathic thrombocytopenic purpura (ITP) is a disorder characterized by increased platelet destruction in the setting of normal megakaryopoiesis. Approximately 20% of patients with ITP are refractory to corticosteroids and splenectomy. Recently, pulse high-dose dexamethasone was reported to be effective in the treatment of chronic ITP in adult patients, We treated 9 patients with severe chronic LTP with monthly high-dose dexamethasone, None of the 9 patients responded with a sustained increase in platelet count, Five of these patients were unable to tolerate the regimen, The failure of high-dose dexamethasone in our hands contrasts with the good results of an earlier publication and suggests that there could be a subset of responders who will require better identification. (C) 1997 Wiley-Liss, Inc.
引用
收藏
页码:267 / 270
页数:4
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