Laser Speckle Contrast Imaging for Measuring Cerebral Blood Flow Changes Caused by Electrical Sensory Stimulation

被引：11
|
作者：
Cho, Ahra [1 ]
Yeon, Chanmi [2 ]
Kim, Donghyeon [3 ]
Chung, Euiheon [1 ,2 ]
机构：
[1] Gwangju Inst Sci & Technol, Sch Mechatron, Gwangju 61005, South Korea
[2] Gwangju Inst Sci & Technol, Dept Med Syst Engn, Gwangju 61005, South Korea
[3] Gwangju Inst Sci & Technol, Sch Informat & Commun, Gwangju 61005, South Korea
来源：
JOURNAL OF THE OPTICAL SOCIETY OF KOREA | 2016年 / 20卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Laser speckle contrast imaging; Cerebral blood flow; Functional activation; Brain imaging; FUNCTIONAL ACTIVATION; NEURONAL-ACTIVITY; DYNAMICS; OXYGENATION; METABOLISM; SIGNAL;
D O I：
10.3807/JOSK.2016.20.1.088
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Recently laser speckle contrast (LSC) imaging has become a widely used optical method for in vivo assessment of blood flow in the animal brain. LSC imaging is useful for monitoring brain hemodynamics with relatively high spatio-temporal resolution. A speckle contrast imaging system has been implemented with electrical sensory stimulation apparatus. LSC imaging is combined with optical intrinsic signal imaging in order to measure changes in cerebral blood flow as well as neural activity in response to electrical sensory stimulation applied to the hindlimb region of the mouse brain. We found that blood flow and oxygen consumption are correlated and both sides of hindlimb activation regions are symmetrically located. This apparatus could be used to monitor spatial or temporal responses of cerebral blood flow in animal disease models such as ischemic stroke or cortical spreading depression.
引用
收藏
页码：88 / 93
页数：6
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