Estrogen receptor β ligands:: Design and synthesis of new 2-phenyl-isoindole-1,3-diones

被引：9
|
作者：
Ullrich, John W.
Unwalla, Rayomand J.
Singhaus, Robert R., Jr.
Harris, Heather A.
Mewshaw, Richard E.
机构：
[1] Wyeth Ayerst Res, Chem & Screening Sci Med Chem, Collegeville, PA 19426 USA
[2] Wyeth Ayerst Res, Chem & Screening Sci Struct Biol, Collegeville, PA 19426 USA
[3] Wyeth Ayerst Res, Womens Hlth & Musculoskeletal Biol, Collegeville, PA 19426 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 01期
关键词：
ER alpha and ER beta receptor; estrogen receptor; nuclear hormone receptor;
D O I：
10.1016/j.bmcl.2006.09.088
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：118 / 122
页数：5
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