A simple one-pot synthesis of functionalised 6-(indol-3-yl)-2,2′-bipyridine derivatives via multi-component reaction under neat condition

被引：39
|
作者：
Thirumurugan, Prakasam [1 ]
Perumal, Paramasivan T. [1 ]
机构：
[1] Cent Leather Res Inst, Div Organ Chem, Madras 600020, Tamil Nadu, India
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 28期
关键词：
6-(Indol-3-yl)-2,2 '-bipyridine; Multi-component reaction; 3-Cyanoacetyl indole; Neat condition; 2,2 '-Bipyridine; Microwave irradiation; Cinnamils; DIELS-ALDER REACTIONS; 3-COMPONENT SYNTHESIS; INDOLE ALKALOIDS; METHODOLOGY; DISCOVERY; PYRIDINES; FACILE;
D O I：
10.1016/j.tetlet.2009.04.121
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 4-aryl-6-(1H-indol-3-yl)-2,2-bipyridine-5-carbonitrile derivatives were synthesized via a one-pot multi-component reaction of aromatic aldehydes, 3-(cyanoacetyl)indole and 2-acetyl pyridine in ammonium acetate by conventional heating and microwave irradiation under solvent-free condition. Also a series of 6,6'-di(1H-indol-3-yl)-4,4'-diaryl-2,2'-bipyridine-5,5'-dicarbonitrile derivatives were synthesized using cinnamils, 3-(cyanoacetyl)indole and ammonium acetate. The methodology affords high yields of product at short reaction time. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4145 / 4150
页数：6
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