Transition Metal-Free sp3 C-H Functionalization of Arylacetic Acids for the Synthesis of 1,3,5-Triazines

被引：10
|
作者：
Pardeshi, Sachin D. [1 ]
Sathe, Pratima A. [1 ]
Pawar, Balu V. [2 ]
Vadagaonkar, Kamlesh S. [3 ]
Chaskar, Atul C. [1 ]
机构：
[1] Univ Mumbai, Natl Ctr Nanosci & Nanotechnol, Bombay 400098, Maharashtra, India
[2] Arts Commerce & Sci Coll, Jawhar, India
[3] Inst Chem Technol, Dept Dyestuff Technol, Bombay 400019, Maharashtra, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 18期
关键词：
Arylacetic acid; Nitrogen heterocycles; Triazenes; C-H Functionalization; Metal-free; REGIOSELECTIVE SYNTHESIS; CYCLIZATION; NITRILES; ALCOHOLS; FACILE; 2,4,6-TRIARYL-1,3,5-TRIAZINES; SOLVENT; AMINES;
D O I：
10.1002/ejoc.201800178
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot simple, efficient and practically viable protocol for the synthesis of substituted 1,3,5-triazines has been reported from arylacetic acids and benzamidine hydrochloride. In addition, we demonstrated first transition metal-free conversion of phenylacetic acid to benzaldehyde which on condensation with two equivalents of benzamidine hydrochloride offered 2,4,6-trisubstituted 1,3,5-triazines. This protocol is environmentally benign and economically viable which makes it feasible for gram scale synthesis.
引用
收藏
页码：2098 / 2102
页数：5
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