Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family

被引：21

作者：

Seki, N

Hattori, A

Hayashi, A

Kozuma, S

Miyajima, N

Saito, T

机构：

[1] Natl Inst Radiol Sci, Genome Res Grp, Inage Ku, Chiba 2638555, Japan

[2] Biotechnol & Med Engn Field, Tokyo, Japan

[3] Kazusa DNA Res Inst, Lab Genome Informat, Chiba, Japan

来源：

JOURNAL OF HUMAN GENETICS | 1999年 / 44卷 / 03期

关键词：

DnaJ; MRJ; MSJ-1; J-domain; chromosome; 11q25;

D O I：

10.1007/s100380050139

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The DnaJ protein family consists of proteins with a highly conserved amino acid stretch called the "J-domain". A cDNA clone encoding a new protein with a J-domain was isolated from a human fetal brain cDNA library. This new member of the DnaJ family of 241 amino acid residues showed 94% identity with mouse Mrj (accession number, AF035962) and 71% identity with mouse Msj-1 (accession number,U95607) along its entire sequence. Reverse transcription - coupled polymerase chain reaction (RT-PCR) analysis showed the messenger RNA was ubiquitously expressed in various human tissues. The chromosomal location of the gene was determined by PCR-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid panel to map on chromosome 11q25 region.

引用

页码：185 / 189

页数：5

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