Metabolism and bioaccumulation of fenvalerate and its metabolites in rat organs

被引：0
|
作者：
Misra, S
Sharma, CB
机构：
来源：
BIOMEDICAL CHROMATOGRAPHY | 1997年 / 11卷 / 01期
关键词：
D O I：
10.1002/(SICI)1099-0801(199701)11:1<50::AID-BMC625>3.3.CO;2-#
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Metabolism and bioaccumulation of fenvalerate and its fenvalerate and its metabolites in liver, kidney and brain of rat following the oral administration of a sub-lethal dose (15 mg/kg) of the pesticide for 7, 15 and 30 day periods was investigated by high-performance liquid chromatography (KPLC) in terms of the relative mole concentrations in rat tissues. The cleavage of the ester linkage in fenvalerate yielding two metabolites was found to be the primary step in the biodegradation of fenvalerate in rat organs, These metabolites were purified to homogeneity by HPLC and characterized by infra-red spectroscopy as 4-chloro-alpha-(1-methylethyl) benzeneacetic acid and 3-phenoxy benzoic acid.
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页码：50 / 53
页数：4
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