The overall development scale of C2C e-commerce in Guangdong province shows the characteristics of major, developing environment presents better. It has solid manufacturing foundation, fairly good logistics infrastructure and network commerce development index. The consumer's buying concept in Guangdong province tends to be fairly novel. But, some challenges also exist, for example, some prominent credit and safety problem still block C2C e-business development. The backward logistics service ability hammers rapid goods delivery. The network buying demand assumes continuous diversity and personality. Some measures should be taken to solve these challenges. For example, to heighten supporting system construction of e-commerce development, to promote actively the application of C2C e-commerce, to pay more attention to the combination of small-and-medium sized enterprise and C2C e-commerce.