Determination of volatile residual solvents in pharmaceutical products by headspace liquid-phase microextraction gas chromatography-flame ionization detector

被引：22
|
作者：
Wang, Xia [1 ]
Jiang, Ting [1 ]
Yuan, Jinpeng [1 ]
Cheng, Chuange [1 ]
Liu, Jianhua [1 ]
Shi, Junbo [1 ]
Zhao, Rusong [1 ]
机构：
[1] Shandong Acad Sci, Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2006年 / 385卷 / 06期
关键词：
volatile residual solvents; HS-LPME; flame ionization detector; pharmaceutical products;
D O I：
10.1007/s00216-006-0506-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l(-1). The limits of detection are 0.2-2.0 mg l(-1) and relative standard deviations (RSD) for most of the volatile solvents were below 10%. This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results.
引用
收藏
页码：1082 / 1086
页数：5
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