Indole and β-carboline alkaloids from Geissospermum sericeum

被引：55
|
作者：
Steele, JCP
Veitch, NC
Kite, GC
Simmonds, MSJ [1 ]
Warhurst, DC
机构：
[1] Royal Bot Gardens, Jodrell Lab, Richmond TW9 3DS, Surrey, England
[2] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England
来源：
JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 01期
关键词：
D O I：
10.1021/np0101705
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N-4-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.
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页码：85 / 88
页数：4
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