Emergence of Vaccine-derived Polloviruses, Democratic Republic of Congo, 2004-2011

被引：27
|
作者：
Gumede, Nicksy [1 ,2 ]
Lentsoane, Olivia [1 ]
Burns, Cara C. [4 ]
Pallansch, Mark [4 ]
de Gourville, Esther [5 ]
Yogolelo, Riziki [6 ]
Muyembe-Tamfum, Jean Jacques [6 ]
Puren, Adrian [1 ]
Schoub, Barry D. [1 ,2 ]
Venter, Marietjie [1 ,3 ]
机构：
[1] Natl Inst Communicable Dis, ZA-2131 Johannesburg, South Africa
[2] Univ Witwatersrand, Johannesburg, South Africa
[3] Univ Pretoria, ZA-0002 Pretoria, South Africa
[4] Ctr Dis Control & Prevent, Atlanta, GA USA
[5] WHO, CH-1211 Geneva, Switzerland
[6] Natl Inst Biomed Res, Kinshasa, DEM REP CONGO
来源：
EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 10期
关键词：
WIDESPREAD CIRCULATION; DEOXYINOSINE RESIDUES; MIXED-BASE; POLIOVIRUS; OUTBREAK; IDENTIFICATION; POLIOMYELITIS; SEROTYPE; PRIMERS; ERADICATION;
D O I：
10.3201/eid1910.130028
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004-2011 were characterized and found to be Vaccine-derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5% in the viral protein 1 capsid region of the viral genome relative to the Sabin vaccine strain. Genetic analysis identified at least 7 circulating lineages localized to specific geographic regions. Multiple independent events of VDPV2 emergence occurred throughout DRC during this 7-year period. During 2010-2011, VDPV2 circulation in eastern DRC occurred in an area distinct from that of wild poliovirus circulation, whereas VDPV2 circulation in the southwestern part of DRC (in Kasai Occidental) occurred within the larger region of wild poliovirus circulation.
引用
收藏
页码：1583 / 1589
页数：7
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