Microwave-assisted preparation of fused bicyclic heteroaryl boronates: Application in one-pot Suzuki couplings

被引：28
|
作者：
DiMauro, EF [1 ]
Vitullo, JR [1 ]
机构：
[1] Amgen Inc, Dept Chem Res & Discovery, Cambridge, MA 02139 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 10期
关键词：
D O I：
10.1021/jo060218p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The rapid and efficient synthesis of various disubstituted 5,6-fused heterocycles using a microwave-assisted one-pot cyclization-Suzuki coupling approach is described. This work highlights the tolerance of the boronic ester functional group to a variety of reaction conditions and the utility of functionalized boronates as penultimate intermediates in the synthesis of diverse compound libraries.
引用
收藏
页码：3959 / 3962
页数：4
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