Potential therapeutic effects of polyphenols in Parkinson's disease: in vivo and in vitro pre-clinical studies

被引：26
|
作者：
Giuliano, Claudio [1 ]
Cerri, Silvia [1 ]
Blandini, Fabio [1 ]
机构：
[1] IRCCS Mondino Fdn, Lab Cellular & Mol Neurobiol, Pavia, Italy
来源：
NEURAL REGENERATION RESEARCH | 2021年 / 16卷 / 02期
关键词：
alpha-synuclein; anti-inflammatory; antioxidants; natural molecules; neuroprotection; Parkinson's disease; polyphenols; syntomatic effect; ALPHA-SYNUCLEIN AGGREGATION; MOUSE MODEL; RAT MODEL; MOTOR IMPAIRMENTS; OXIDATIVE STRESS; RESVERATROL; 6-HYDROXYDOPAMINE; ANTIOXIDANT; ACTIVATION; NARINGENIN;
D O I：
10.4103/1673-5374.290879
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Parkinson's disease is a neurodegenerative disorder characterized by a combination of severe motor and non-motor symptoms. Over the years, several factors have been discovered to play a role in the pathogenesis of this disease, in particular, neuroinflammation and oxidative stress. To date, the pharmacological treatments used in Parkinson's disease are exclusively symptomatic. For this reason, in recent years, the research has been directed towards the discovery and study of new natural molecules to develop potential neuroprotective therapies against Parkinson's disease. In this context, natural polyphenols have raised much attention for their important anti-inflammatory and antioxidant properties, but also for their ability to modulate protein misfolding. In this review, we propose to summarize the relevant in vivo and in vitro studies concerning the potential therapeutic role of natural polyphenols in Parkinson's disease.
引用
收藏
页码：234 / 241
页数：8
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