Sex-specific effects of prenatal stress on neuronal development in the medial prefrontal cortex and the hippocampus

被引：26
|
作者：
Suenaga, Toshiko [1 ]
Yukie, Masao [2 ]
Gao, Shuibo [1 ]
Nakahara, Daiichiro [1 ]
机构：
[1] Hamamatsu Univ Sch Med, Dept Psychol & Behav Neurosci, Hamamatsu, Shizuoka 4313192, Japan
[2] Int Univ Hlth & Welf, Dept Orthopt & Visual Sci, Ohtawara, Tochigi, Japan
来源：
NEUROREPORT | 2012年 / 23卷 / 07期
关键词：
dendritic morphology; Golgi stain; hippocampus; medial prefrontal cortex; prenatal stress; sex differences; LEARNING-DEFICITS; MATERNAL STRESS; GESTATIONAL STRESS; SPATIAL MEMORY; SECRETION; DENSITY; MAZE; RATS;
D O I：
10.1097/WNR.0b013e3283529805
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Evidence suggests that maternal stress during gestation in humans and animals can cause emotional and cognitive dysfunction in the offspring. In the present study, we examined neurons of the hippocampus and the medial prefrontal cortex of adult rats exposed to prenatal stress. Using a revised Golgi-Cox staining method, we found decreases in dendritic length and complexity in area CA3 and the dentate gyrus of male rats exposed to prenatal stress compared with the controls, as well as decreased dendritic complexity in the prelimbic cortex. In contrast, we did not detect any changes in dendrites of female rats exposed to prenatal stress. Our results suggest that prenatal stress can induce long-lasting morphological changes in the medial prefrontal cortex and the hippocampus that are sex specific. NeuroReport 23:430-435 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：430 / 435
页数：6
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