(R)-4-[2-(Methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-3-yl)-1H-pyrazol-5-amine

被引：1
|
作者：
Liu, Zhengyu [1 ]
Liu, Kevin K-C. [1 ]
Elleraas, Jeff [1 ]
Rheingold, Arnold L. [2 ]
DiPasquale, Antonio [2 ]
Yanovsky, Alex [1 ]
机构：
[1] Pfizer Global Res & Dev, La Jolla Labs, San Diego, CA 92121 USA
[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷
关键词：
D O I：
10.1107/S160053680900734X
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compound, C12H15N5OS, was obtained by reaction of 2-(2-(methylthio) pyrimidin-4-yl)-3-oxopropanenitrile with (tetrahydrofuran-3-yl) hydrazine dihydrochloride, and the racemic product was subsequently separated by chiral chromatography (first peak; [alpha](D)(20) = + 51.3 degrees). The chiral center at the substituted atom of the tetrahydrofuranyl group has an R-configuration. The pyrimidine and pyrazolyl rings are almost coplanar, their mean planes forming a dihedral angle of 6.4 (1)degrees. One of the H atoms of the amino group participates in an intramolecular hydrogen bond with the pyrimidine N atom in position 3. The second H atom is involved in an intermolecular hydrogen bond, which links the molecules into an infinite chain.
引用
收藏
页码：O697 / U1504
页数：10
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