Acid-Degradable Polymer-Caged Lipoplex (PCL) Platform for siRNA Delivery: Facile Cellular Triggered Release of siRNA

被引：68
|
作者：
Hong, Bong Jin [1 ]
Chipre, Anthony J. [1 ]
Nguyen, SonBinh T. [1 ]
机构：
[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 47期
关键词：
IN-VIVO; CATIONIC LIPIDS; GENE DELIVERY; NANOPARTICLES; EFFICIENT; NANOBINS; CELLS; LIPOSOMES; SYSTEM; VITRO;
D O I：
10.1021/ja404491r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An acid-degradable polymer-caged lipoplex (PCL) platform consisting of a cationic lipoplex core and a biocompatible, pH-responsive polymer shell has been developed for the effective delivery of small interfering RNA (siRNA) through a combination of facile loading, rapid acid-triggered release, cellular internalization, and effective endosomal escape. In vitro testing of this degradable PCL delivery platform reveals similar to 45 and similar to 2.5-fold enhancement of enhanced green fluorescent protein knockdown in cancer cells in comparison to either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.
引用
收藏
页码：17655 / 17658
页数：4
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