Clinical and research markers of oxidative stress in chronic kidney disease

被引:98
|
作者
Tucker, Patrick Steven [1 ]
Dalbo, Vincent James [1 ]
Han, Thin [2 ]
Kingsley, Michael Ian [3 ]
机构
[1] Cent Queensland Univ, Inst Hlth & Social Sci Res, Clin Biochem Lab, Rockhampton, Qld 4702, Australia
[2] Rockhampton Hosp, Cent Queensland Hlth Serv Dist, Renal Serv, Rockhampton, Qld, Australia
[3] La Trobe Univ, La Trobe Rural Hlth Sch, Melbourne, Vic 3550, Australia
关键词
Antioxidant status; reactive nitrogen species; reactive oxygen species; renal disease; renal failure; STAGE RENAL-DISEASE; ASYMMETRIC DIMETHYLARGININE ADMA; PLASMA ANTIOXIDANT CAPACITY; ACID REACTIVE SUBSTANCES; INTIMA-MEDIA THICKNESS; E-BONDED MEMBRANE; LIPID-PEROXIDATION; VITAMIN-E; PERITONEAL-DIALYSIS; PROTEIN PRODUCTS;
D O I
10.3109/1354750X.2012.749302
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Context: Kidney-related pathologies have increasing prevalence rates, produce a considerable financial burden, and are characterized by elevated levels of oxidative stress (OS). Objective: This review examines relationships between chronic kidney disease (CKD) and markers of OS and antioxidant status (AS). Methods: A systematic review of MEDLINE-indexed clinical trials, randomized controlled trials and comparative studies that examined OS and AS was performed. Results and conclusion: Several markers emerged as well-suited indicators of OS and AS in CKD: malondialdehyde, F2-isoprostanes, lipid hydroperoxides, asymmetric dimethylarginine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, protein carbonyls, advanced oxidation protein products and glutathione-related activity.
引用
收藏
页码:103 / 115
页数:13
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