Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus

被引：38
|
作者：
Ghaderkhani, Jalal [1 ]
Yousefimashouf, Rasoul [1 ]
Arabestani, Mohammadreza [1 ]
Roshanaei, Ghodratollah [2 ]
Asl, Sara Soleimani [3 ]
Abbasalipourkabir, Roghayeh [4 ]
机构：
[1] Hamadan Univ Med Sci, Dept Microbiol, Hamadan, Iran
[2] Hamadan Univ Med Sci, Modeling Noncommunicable Dis Res Ctr, Sch Publ Hlth, Dept Biostat & Epidemiol, Hamadan, Iran
[3] Hamadan Univ Med Sci, Endometrium & Endometriosis Res Ctr, Hamadan, Iran
[4] Hamadan Univ Med Sci, Dept Biochem, Hamadan, Iran
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2019年 / 47卷 / 01期
关键词：
Solid lipid nanoparticles; rifampicin; antibacterial activity; Brucella abortus; IN-VITRO; DELIVERY-SYSTEMS; STEARIC-ACID; FORMULATION; CRYSTALLINITY; ENCAPSULATION; STREPTOMYCIN; MACROPHAGES; MELITENSIS; STABILITY;
D O I：
10.1080/21691401.2019.1593858
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319.7 nm, PI about 0.20 and zeta potential about 18.4 mv, encapsulation efficacy and drug-loading were equal to 95.78 and 34.2%, respectively, with a spherical shape. Drug release lasted for 5 days. The antibacterial activity was statistically significant with rho < .05 in bacterial and cell culture media compared to free Rifampicin. It can be concluded that solid lipid nanoparticles can be considered as a promising delivery system for improving the antibacterial activity of Rifampicin against Brucella abortus.
引用
收藏
页码：1181 / 1193
页数：13
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