Metabotropic glutamate receptor 5 in bulimia nervosa

被引：10
|
作者：
Mihov, Yoan [1 ,6 ]
Treyer, Valerie [2 ]
Akkus, Funda [1 ]
Toman, Erika [3 ]
Milos, Gabriella [4 ]
Ametamey, Simon M. [5 ]
Johayem, Anass [2 ]
Hasler, Gregor [1 ,6 ]
机构：
[1] Univ Bern, Univ Hosp Psychiat & Psychotherapy, Translat Res Ctr, Bern, Switzerland
[2] Univ Zurich, Univ Hosp Zurich, Dept Nucl Med, CH-8091 Zurich, Switzerland
[3] Competence Network Eating Disorders, Forchstr 132, CH-8032 Zurich, Switzerland
[4] Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Culmannstr 8, CH-8091 Zurich, Switzerland
[5] ETH, Dept Chem & Appl Biosci, Ctr Radiopharmaceut Sci ETH PSI & USZ, CH-8093 Zurich, Switzerland
[6] Univ Fribourg, Psychiat Res Unit, Chemin Cardinal Journet 3, CH-1752 Villars Sur Glane, Switzerland
来源：
SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期
关键词：
CATECHOLAMINE DEPLETION; PRECLINICAL EVALUATION; ORBITOFRONTAL CORTEX; COCAINE ADDICTION; REMITTED SUBJECTS; FOOD; PET; REWARD; INVENTORY; DISORDER;
D O I：
10.1038/s41598-020-63389-7
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo in 15 female subjects with BN and 15 matched controls. We measured mGlu5 distribution volume ratio (DVR) with positron emission tomography (PET) using [11C]ABP688. In BN mGlu5 DVR was higher in the anterior cingulate cortex (ACC), subgenual prefrontal cortex, and straight gyrus (p<0.05). In BN, higher mGlu5 DVR in various brain regions, including ACC, pallidum, putamen, and caudate, positively correlated with "maturity fears" as assessed using the Eating Disorder Inventory-2 (p<0.05). In BN and controls, smokers had globally decreased mGlu5 DVR. We present the first evidence for increased mGlu5 DVR in BN. Our findings suggest that pharmacological agents inhibiting mGlu5 might have a therapeutic potential in BN.
引用
收藏
页数：10
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