Cytotoxic cardenolides from the root bark of Calotropis gigantea

被引：26
|
作者：
You, Hanyun [1 ]
Lei, Min [2 ]
Song, Weibin [1 ]
Chen, Hu [1 ]
Meng, Yuhui [2 ]
Guo, Dean [2 ]
Liu, Xuan [2 ]
Hu, Lihong [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
来源：
STEROIDS | 2013年 / 78卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Antitumor agent; Calotropis gigantea; Asclepiadaceae; Cardenolide; Cytotoxicity; CARDIAC-GLYCOSIDES; ASCLEPIAS-CURASSAVICA; PROCERA; PRINCIPLES; LEAVES; CELLS; DRUG;
D O I：
10.1016/j.steroids.2013.06.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six new cardenolides (1, 2 and 11-14), along with ten known ones, were isolated from the root bark of Calotropis gigantea. The structural determination was accomplished by the 1D- and 2D-NMR spectrum as well as ESIMS analysis. The isolated compounds were evaluated for their in vitro growth inhibitory activity against human A549 and Hela cell lines. The results suggested that some of these cardenolides (compounds 1, 6, and 8) displayed potent cytotoxicities. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：1029 / 1034
页数：6
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