A new dimeric carbazole alkaloid from Murraya koenigii (L.) leaves with α-amylase and α-glucosidase inhibitory activities

被引：9

作者：

Sampath, Sepala Nupage Thushara Indika ^{[1
,2
]}

Jayasinghe, Susanthi ^{[1
,2
,5
]}

Attanayake, Anoja Priyadarshani ^{[3
]}

Karunaratne, Veranja ^{[1
]}

Yaddehige, Mahesh Loku ^{[4
]}

Watkins, Davita L. ^{[4
]}

机构：

[1] Univ Peradeniya, Fac Sci, Dept Chem, Peradeniya, Sri Lanka

[2] Univ Peradeniya, Postgrad Inst Sci, Peradeniya, Sri Lanka

[3] Univ Ruhuna, Fac Med, Dept Biochem, Ruhuna, Sri Lanka

[4] Univ Mississippi, Dept Chem & Biochem, Oxford, MI 38677 USA

[5] Univ Peradeniya, Fac Sci, Dept Chem, Peradeniya 20400, Sri Lanka

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 52卷

关键词：

Murraya koenigii; New dimeric carbazole alkaloid; -Amylase; -Glucosidase; Percent inhibitory activity; IN-VITRO; EXTRACT;

D O I：

10.1016/j.phytol.2022.09.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new dimeric carbazole alkaloid, 3,3 ',5,5 ',8-pentamethyl-3,3 '-bis(4-methylpent-3-en-1-yl)-3,3 ',11,11 '-tetrahy-dro-10,10 '-bipyrano[3,2-a]carbazole, was isolated from the hexane extract of leaves of Murraya koenigii (L.) Sprengel. (Family: Rutaceae). The structure was elucidated based on 13C and 1H NMR, High-Resolution Mass Spectrometry (HRMS), and 2D NMR data. The in vitro antidiabetic activity of the new dimer was investigated in terms of alpha-amylase and alpha-glucosidase enzyme inhibition assays. The dimer exhibited significant alpha-amylase inhibitory activity (IC50 = 30.32 +/- 0.34 ppm) and alpha-glucosidase inhibitory activity (IC50 = 30.91 +/- 0.36 ppm).

引用

页码：87 / 91

页数：5

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