Intramolecular benzyl protection delivery:: A practical synthesis of DMDP and DGDP from D-fructose

被引：31
|
作者：
García-Moreno, MI
Aguilar, M
Mellet, CO
Fernández, JMG
机构：
[1] Univ Seville, Fac Quim, Dept Quim Organ, E-41071 Seville, Spain
[2] CSIC, Inst Invest Quim, E-41092 Seville, Spain
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 02期
关键词：
D O I：
10.1021/ol052668u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A two-step protection of 1,2-diols as the corresponding o-xylylene cyclic ethers, involving an intramolecular ring-closing O-benzylation reaction, has been developed to overcome the problems associated to regioselective benzylation reactions. The strategy has been applied to the high-yielding synthesis of the pyrrolidine glycosidase inhibitors DMDP and DGDP.
引用
收藏
页码：297 / 299
页数：3
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