Cimetidine inhibits the induction of long-term potentiation in the dentate gyrus of rats in vivo

被引：5
|
作者：
Chang, M [1 ]
Saito, H [1 ]
Abe, K [1 ]
机构：
[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,BUNKYO KU,TOKYO 113,JAPAN
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 74卷 / 03期
关键词：
cimetidine; long-term potentiation; hippocampus;
D O I：
10.1254/jjp.74.281
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effect of cimetidine, a clinically used H-2-receptor antagonist, on the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats. Intracerebroventricular injection of cimetidine (50-100 nmol) inhibited the induction of LTP in a dose-dependent manner. The inhibitory effect of cimetidine was not mimicked by other H-2-receptor antagonists (ranitidine, famotidine) or the H-1-receptor antagonist diphenhydramine or the H(3-)receptor antagonist thioperamide. These results suggest that cimetidine inhibits hippocampal synaptic plasticity by a novel brain mechanism unrelated to H-1, H-2 or H-3 receptors.
引用
收藏
页码：281 / 283
页数：3
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