Malignant transformation of oral lichen planus

被引:72
|
作者
Rajentheran, R
McLean, NR
Kelly, CG
Reed, MF
Nolan, A
机构
[1] Newcastle Univ, Sch Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Royal Victoria Infirm, Dept Plast & Reconstruct Surg, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
[3] Newcastle Gen Hosp, No Ctr Canc Treatment, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England
[4] Dent Hosp, Dept Oral Pathol, Newcastle Upon Tyne, Tyne & Wear, England
来源
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY | 1999年 / 25卷 / 05期
关键词
cancer; oral lichen planus; oral squamous cell carcinoma; pre-malignant lesion;
D O I
10.1053/ejso.1999.0689
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims: To investigate the malignant potential of oral lichen planus (OLP), a common mucocutaneous disease of unknown aetiology. The malignant potential of OLP is still controversial, with studies reporting malignant transformation rates of between 0 and 5.6%. We also aimed to identify factors that might be associated with malignant transformation. Methods: We retrospectively reviewed the records of 832 patients with histologically confirmed OLP treated at the Dental Hospital, Newcastle upon Tyne during the period 1983-1996. Results: Of these 832 patients, a total of seven (0.8%) developed intra-oral squamous cell carcinoma (SCC), including three cases of carcinoma in situ. It was noted that OLP patients with SCC are more likely to be women, relatively young and have a low tobacco and alcohol intake. However, they had a good long-term prognosis. Conclusions: We conclude that the risk of malignant transformation in OLP is real but not high. Clinicians should have a higher index of suspicion of the possibility of malignancy developing in OLP, because such patients are different from typical patients who develop oral malignancy. Follow-up for at least 6 years is recommended.
引用
收藏
页码:520 / 523
页数:4
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