The Alzheimer's Association International Conference (AAIC) remains the leading and largest international meeting dedicated to advancing dementia science. The 2022 meeting was held from July 31 to August 4 in San Diego, California, USA, as an in-person event and allowed virtual attendance. Every year, AAIC gathers the world's leading basic science and clinical researchers, clinicians, next-generation investigators and the care research community for sharing discoveries that aim at the preventive and treatment methods as well as the improvements in the diagnosis of Alzheimer's disease. Approximately 650 podium presentations and more than 3,000 poster presentations on the fields of basic science, imaging, emerging research, novel practice techniques, technologies and more were available to attendees along with vast networking opportunities.