Tocilizumab Monotherapy in a Patient with Rheumatoid Arthritis and Iatrogenic Kaposi Sarcoma

被引：6
|
作者：
Ingegnoli, Francesca [1 ]
Tourlaki, Athanasia [2 ]
Gualtierotti, Roberta [1 ]
机构：
[1] Univ Milan, Div Rheumatol, Ist Gaetano Pini, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy
[2] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dermatol Unit, Milan, Italy
来源：
CLINICAL DRUG INVESTIGATION | 2014年 / 34卷 / 02期
关键词：
CASTLEMANS-DISEASE; RECEPTOR ANTIBODY; IL-6; RECEPTOR;
D O I：
10.1007/s40261-013-0159-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Kaposi sarcoma (KS) is a human herpesvirus-8-associated lymphoangioproliferative neoplasm. Both human and viral interleukin-6 (IL-6) proteins seem to drive much of the clinical manifestations of KS, which provides a new target for intervention by using IL-6-neutralizing antibodies. We describe the clinical course of a patient in whom tocilizumab, a monoclonal anti-IL-6 receptor antibody approved for rheumatoid arthritis (RA) treatment, was effective not only in inducing RA remission but was also safe for KS.
引用
收藏
页码：159 / 161
页数：3
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