Femtosecond two-photon excited fluorescence of melanin

被引：1
|
作者：
Teuchner, K
Freyer, W
Leupold, D
Volkmer, A
Birch, DJS
Altmeyer, P
Stücker, M
Hoffmann, K
机构：
[1] Max Born Inst Nonlinear Opt & Short Pulse Spect, D-12489 Berlin, Germany
[2] Univ Strathclyde, Dept Phys & Appl Phys, Photophys Res Grp, Glasgow, Lanark, Scotland
[3] Ruhr Univ Bochum, St Josef Hosp, Dept Dermatol, D-4630 Bochum, Germany
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1999年 / 70卷 / 02期
关键词：
D O I：
10.1562/0031-8655(1999)070<0146:FTPEFO>2.3.CO;2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fluorescence of synthetic melanin in dimethyl sulfoxide has been excited by two-photon absorption at 800 nm, using 120 fs pulses with photon flux densities greater than or equal to 10(27) cm(-2) s(-1). The shortest main component of the three-exponential decay of fluorescence is 200 +/- 2 ps. The overall spectral shape is red-shifted with respect to the 400 nm excited fluorescence. Two-photon excited melanin fluorescence also has been measured from excised samples of healthy human skin tissue. Because of the selectivity of melanin excitation via resonant two-photon absorption, it is hypothesized that fluorescence excited in this way may yield information on malignant transformation.
引用
收藏
页码：146 / 151
页数：6
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