Tumour Microenvironment in Skin Carcinogenesis

被引:45
|
作者
Georgescu, Simona Roxana [1 ,2 ]
Tampa, Mircea [1 ,2 ]
Mitran, Cristina Iulia [1 ,3 ]
Mitran, Madalina Irina [1 ,3 ]
Caruntu, Constantin [1 ,4 ]
Caruntu, Ana [5 ,6 ]
Lupu, Mihai [7 ]
Matei, Clara [1 ]
Constantin, Carolina [8 ,9 ]
Neagu, Monica [8 ,9 ,10 ]
机构
[1] Carol Davila Univ Med & Pharm, Bucharest, Romania
[2] Victor Babes Clin Hosp Infect Dis, Bucharest, Romania
[3] Cantacuzino Natl Med Mil Inst Res & Dev, Bucharest, Romania
[4] Prof N Paulescu Natl Inst Diabet Nutr & Metab Dis, Dept Dermatol, Bucharest, Romania
[5] Carol Davila Cent Mil Emergency Hosp, Dept Oral & Maxillofacial Surg, Bucharest, Romania
[6] Titu Maiorescu Univ, Dept Preclin Sci, Fac Med, Bucharest, Romania
[7] MEDAS Med Ctr, Dept Dermatol, Bucharest, Romania
[8] Victor Babes Natl Inst Pathol, Dept Immunol, Bucharest, Romania
[9] Colentina Clin Hosp, Bucharest, Romania
[10] Univ Bucharest, Fac Biol, Bucharest, Romania
关键词
Skin cancer; Basal cell carcinoma; Squamous cell carcinoma; Cutaneous melanoma; Tumour microenvironment; Reflectance confocal microscopy; BASAL-CELL CARCINOMA; INFILTRATING LYMPHOCYTES; EXTRACELLULAR-MATRIX; MELANOMA DEVELOPMENT; HEAD; MACROPHAGES; CYTOKINES; CANCER; EXPRESSION; THERAPY;
D O I
10.1007/978-3-030-36214-0_10
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumour microenvironment is a complex system comprising cells and molecules that will provide the necessary conditions for tumour development and progression. Cells residing in the tumour microenvironment gain specific phenotypes and specific functions that are pro-tumorigenic. Tumour progression is in fact a combination between tumour cell characteristics and its interplay with tumour microenvironment. This dynamic network will allow tumour cells to grow, migrate and invade tissues. In the present chapter, we are highlighting some traits that characterise tumour microenvironment in basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma. In skin cancers, there are some common tumour microenvironment characteristics such as the presence of tumour-associated macrophages and regulatory T lymphocytes that are non-tumour cells promoting tumorigenesis. There are also skin cancer type differences in terms of tumour microenvironment characteristics. Thus, markers such as macrophage migration inhibitory factor in melanoma or the extraordinary diverse genetic make-up in the cancer-associated fibroblasts associated to squamous cell carcinoma are just a few of specific traits in skin cancer types. New technological advances for evaluation of tumour environment are presented. Thus, non-invasive skin imaging techniques such as reflectance confocal microscopy can evaluate skin tumour inflammatory infiltrates for density and cellular populations. Analysing tumour micromedium in depth may offer new insights into cancer therapy and identify new therapy targets.
引用
收藏
页码:123 / 142
页数:20
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