Cinchona Alkaloid-catalyzed Asymmetric Direct Mannich Reaction of Malononitrile to Imine for Synthesis of β-Amino Malononitrile

被引：13

作者：

Lu Zhijin ^{[1
]}

Xie Chen ^{[1
]}

Zhou Wei ^{[1
]}

Duan Zhiqiang ^{[1
]}

Han Jianlin ^{[1
]}

Pan Yi ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat, Nanjing 210093, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 10期

基金：

中国国家自然科学基金;

关键词：

asymmetric Mannich reaction; cinchona alkaloids; ss-amino Malononitrile; imines; ACYL CYANIDE REAGENTS; ENANTIOSELECTIVE SYNTHESIS; ACID; PRECURSORS; ALDEHYDES; ADDITIONS; ESTERS; ANION;

D O I：

10.1002/cjoc.201200586

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first direct asymmetric Mannich reaction of malononitrile to N-Boc-protected imines has been developed with cinchona alkaloid as catalyst. The procedure could tolerate a relatively wide range of substrates, and results in excellent yields and good enantioselectivities even in the presence of only 1 mol% of catalyst loading. The present work provides an easy access to beta-amino malononitrile derivatives.

引用

页码：2333 / 2337

页数：5

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