Hsp90, the concertmaster: tuning transcription

被引:49
|
作者
Khurana, Nidhi [1 ]
Bhattacharyya, Sunanda [1 ]
机构
[1] Univ Hyderabad, Sch Life Sci, Dept Biotechnol & Bioinformat, Hyderabad 500046, Andhra Pradesh, India
来源
FRONTIERS IN ONCOLOGY | 2015年 / 5卷
关键词
Hsp90; transcription; chromatin modifiers; transcription factors; cancer; HEAT-SHOCK PROTEINS; MOLECULAR CHAPERONE; ANDROGEN RECEPTOR; CANCER-CELLS; DNA METHYLTRANSFERASE-1; GENE-EXPRESSION; MUTANT P53; COMPLEX; PROLIFERATION; SMYD3;
D O I
10.3389/fonc.2015.00100
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In the last decade, Hsp90 has emerged as a major regulator of cancer cell growth and proliferation. In cancer cells, it assists in giving maturation to oncogenic proteins including several kinases and transcription factors (IF). Recent studies have shown that apart from its chaperone activity, it also imparts regulation of transcription machinery and thereby alters the cellular physiology. Hsp90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain TFs in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. In this review, we discuss the role of Hsp90 in all the three aforementioned mechanisms of transcriptional control, taking examples from various model organisms with a special emphasis on cancer progression.
引用
收藏
页数:7
相关论文
共 50 条
  • [1] Effect of geldanamycin on transcription of Hsp90α and Hsp90β genes in brain of goldfish
    Morishige, Kota
    Kagawa, Nao
    [J]. ZOOLOGICAL SCIENCE, 2006, 23 (12) : 1212 - 1212
  • [2] Orchardgrass ACTIVATOR OF HSP90 ATPASE possesses autonomous chaperone properties and activates Hsp90 transcription to enhance thermotolerance
    Lee, Changhoon
    Youn, Ho Jin
    Lee, Sang-Hoon
    Kim, Jinwoo
    Son, Daeyoung
    Cha, Joon-Yung
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 586 : 171 - 176
  • [3] Overview: Translating Hsp90 Biology into Hsp90 Drugs
    Workman, Paul
    [J]. CURRENT CANCER DRUG TARGETS, 2003, 3 (05) : 297 - 300
  • [4] A comparison of Hsp90α and Hsp90β interactions with cochaperones and substrates
    Taherian, Aliakbar
    Krone, Patrick H.
    Ovsenek, Nick
    [J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2008, 86 (01): : 37 - 45
  • [5] Molecular Variation of Human HSP90α and HSP90β Genes in Caucasians
    Passarino, Giuseppe
    Cavalleri, Gianpiero L.
    Stecconi, Rosalia
    Franceschi, Claudio
    Altomare, Katia
    Dato, Serena
    Greco, Valentina
    Sforza, L. Luca Cavalli
    Underhill, Peter A.
    de Benedictis, Giovanna
    [J]. HUMAN MUTATION, 2003, 21 (05)
  • [6] Biology of HSP90
    Workman, P.
    [J]. ANNALS OF ONCOLOGY, 2008, 19 : 17 - 18
  • [7] Modulators of HSP90
    不详
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (06) : 425 - 425
  • [8] Biology of HSP90
    Neckers, L.
    [J]. ANNALS OF ONCOLOGY, 2008, 19 : 17 - 17
  • [9] Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90
    Kotwal, Akhil
    Subbarao, Sreedhar Amere
    [J]. CELLULAR SIGNALLING, 2020, 76
  • [10] The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
    Chang, Cheng
    Tang, Xin
    Woodley, David T.
    Chen, Mei
    Li, Wei
    [J]. CELLS, 2023, 12 (02)