Synthesis of Biodegradable Poly-ε-caprolactone Microspheres by Dispersion Ring-Opening Polymerization in Supercritical Carbon Dioxide

被引：16
|
作者：
Grignard, Bruno [1 ]
Stassin, Fabrice [1 ]
Calberg, Cedric [1 ]
Jerome, Robert [1 ]
Jerome, Christine [1 ]
机构：
[1] Univ Liege, Ctr Educ & Res Macromol, B-4000 Liege, Belgium
来源：
BIOMACROMOLECULES | 2008年 / 9卷 / 11期
关键词：
D O I：
10.1021/bm800730m
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of fluorinated diblock and triblock copolymers of poly (epsilon-caprolactone) and poly(heptadecafluorodecylacrylate) were prepared by combining ring-opening polymerization of epsilon-CL and atom transfer radical polymerization of the acrylate. These copolymers with well-controlled molecular weight and composition were characterized by H-1 NMR spectroscopy and used as stabilizers for the dispersion ring-opening polymerization of epsilon-CL in supercritical carbon dioxide. The effect of composition and architecture of the polymeric stabilizers on the stabilization of PCL microspheres was investigated. Finally, purification of PCL was successfully implemented by reactive supercritical fluid extraction of the tin catalyst.
引用
收藏
页码：3141 / 3149
页数：9
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