Development of a new silicone base transdermal system.: III.: Study of thermal properties of silicone elastomers containing liquid ingredients

In present work we have investigated the commonly used base silicone elastomers namely cured poly-dimethyl-siloxanes and the change of the inner polarity of silicone elastomers containing various amounts of polar liquid ingredients and trifunctional silicone additives. It was shown that the polarity of the inside of the matrix is related to the diffusion properties of model substances and thermal properties of silicone elastomers. The ingredients used have changed the matrix framework, that was influenced by the type of trifunctional additive too. These properties show large dependence on the timing of the measurement. Measurements carried out after 48 hour of the production of the polymer showed reproducible properties, indicating that the final structure of the polymer has been formed. These results show that the ingredients influence the properties of the silicone matrices considerably, thus the characteristics of the drug release of pharmaceutical forms can be varied too.