Synthesis and bioactivity of 5-Ivermectin B1a esters

被引：0

作者：

Liao, LA ^{[1
]}

Li, ZM

Fang, HY

Zhao, WG

Fan, ZJ

Liu, GJ

机构：

[1] Xiamen Univ, Dept Chem, Xiamen 361005, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ACTA CHIMICA SINICA | 2002年 / 60卷 / 03期

关键词：

esterification; 5-Ivermectin B-1a; bioactivity; DMAP/DCC;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ten 5-Ivermectin B-1a ester derivatives were prepared from Ivermectin B-1a and carboxylic acids in the systems of DCC/DMAP. Their chemical structures were determined by IR, H-1 NMR, C-13 NMR. and MS spectra. The preliminary results of bioassay showed that L-1 similar to L-10 have good insecticidal activities.

引用

页码：468 / 474

页数：7

共 11 条

[1] AN INTRODUCTION TO THE AVERMECTINS
CAMPBELL, WC
[J]. NEW ZEALAND VETERINARY JOURNAL, 1981, 29 (10) : 174 - 178
[2] DAOQUAN W, 1994, AGR U PEKINENSIS, V20, P431
[3] Control of gastrointestinal nematodes in first season grazing calves by two strategic treatments with eprinomectin
Dorny, P
Demeulenaere, D
Smets, K
Vercruysse, J
[J]. VETERINARY PARASITOLOGY, 2000, 89 (04) : 277 - 286
[4] RECENT ADVANCES IN AVERMECTIN RESEARCH
FISHER, MH
[J]. PURE AND APPLIED CHEMISTRY, 1990, 62 (07) : 1231 - 1240
[5] LIANAN L, 1998, CHEM ENG PROG, V17, P43
[6] GLYCOSIDATION ROUTE TO 4''-EPI-(METHYLAMINO)-4''-DEOXYAVERMECTIN B-1 (MK-244, EMAMECTIN BENZOATE)
LOEWE, MF
CVETOVICH, RJ
DIMICHELE, LM
SHUMAN, RF
GRABOWSKI, EJJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (25): : 7870 - 7875
[7] THE TREATMENT OF SCABIES WITH IVERMECTIN
MEINKING, TL
TAPLIN, D
HERMIDA, JL
PARDO, R
KERDEL, FA
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (01): : 26 - 30
[8] MROZIK HH, 1980, Patent No. 4201861
[9] MU LY, 1994, RES METHOD PLANT CHE, P56
[10] AVERMECTIN-MILBEMYCIN STUDIES .2. AN EFFICIENT CHEMICAL DEGRADATION OF AVERMECTIN-B
SMITH, AB
THOMPSON, AS
[J]. TETRAHEDRON LETTERS, 1985, 26 (36) : 4279 - 4282

← 1 2 →