Photodynamic Therapy Mediated by Hypericin, a Natural Endoplasmic Reticulum-localized Drug, Activates Autophagic Pathways That Increase the Resistance to the Therapy

被引:0
|
作者
Rubio, N. [1 ]
Verrax, J. [1 ]
Dewaele, M. [1 ]
Piette, J. [2 ]
Agostinis, P. [1 ]
机构
[1] Katholieke Univ Leuven, Cellular & Mol Med, Louvain, Belgium
[2] Univ Liege, Liege, Belgium
关键词
D O I
10.1016/S0959-8049(12)71072-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
388
引用
收藏
页码:S94 / S94
页数:1
相关论文
共 25 条
  • [1] Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications
    Nam, Jung Seung
    Kang, Myeong-Gyun
    Kang, Juhye
    Park, Sun-Young
    Lee, Shin Jung C.
    Kim, Hyun-Tak
    Seo, Jeong Kon
    Kwon, Oh-Hoon
    Lim, Mi Hee
    Rhee, Hyun-Woo
    Kwon, Tae-Hyuk
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (34) : 10968 - 10977
  • [2] Endoplasmic Reticulum-Localized Two-Photon-Absorbing Boron Dipyrromethenes as Advanced Photosensitizers for Photodynamic Therapy
    Zhou, Yimin
    Cheung, Ying-Kit
    Ma, Chao
    Zhao, Shirui
    Gao, Di
    Lo, Pui-Chi
    Fong, Wing-Ping
    Wong, Kam Sing
    Ng, Dennis K. P.
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (09) : 3952 - 3961
  • [3] An epidermal growth factor receptor-targeted and endoplasmic reticulum-localized organic photosensitizer toward photodynamic anticancer therapy
    Zhao, Xuan
    Ma, Haixia
    Chen, Juanjuan
    Zhang, Fengling
    Jia, Xiao
    Xue, Jinping
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 182
  • [4] Breast cancer resistance protein is the enemy of hypericin accumulation and toxicity of hypericin-mediated photodynamic therapy
    Jendzelovsky, Rastislav
    Jendzelovska, Zuzana
    Kucharova, Barbora
    Fedorocko, Peter
    BIOMEDICINE & PHARMACOTHERAPY, 2019, 109 : 2173 - 2181
  • [5] Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy
    Buytaert, Esther
    Callewaert, Geert
    Hendrickx, Nico
    Scorrano, Luca
    Hartmann, Dieter
    Missiaen, Ludwig
    Vandenheede, Jackie R.
    Heirman, Ingeborg
    Grooten, Johan
    Agostinis, Patrizia
    FASEB JOURNAL, 2006, 20 (02): : 756 - +
  • [6] Mitochondria-associated endoplasmic reticulum membranes microenvironment: targeting autophagic and apoptotic pathways in cancer therapy
    Patergnani, Simone
    Missiroli, Sonia
    Marchi, Saverio
    Giorgi, Carlotta
    FRONTIERS IN ONCOLOGY, 2015, 5
  • [7] An endoplasmic reticulum and lipid droplets dual-localized strategy to develop small molecular photosensitizers that induce ferroptosis during photodynamic therapy
    Kang, Ke
    Wu, You
    Zhang, Xi
    Wang, Shuqi
    Ni, Shaokai
    Shao, Jiaan
    Du, Yushen
    Yu, Yongping
    Shen, Yong
    Chen, Yiding
    Chen, Wenteng
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 286
  • [8] Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro
    Khdair, Ayman
    Handa, Hitesh
    Mao, Guangzhao
    Panyam, Jayanth
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2009, 71 (02) : 214 - 222
  • [9] Nano particle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance
    Khdair, Ayman
    Chen, Di
    Patil, Yogesh
    Ma, Linan
    Dou, Q. Ping
    Shekhar, Malathy P. V.
    Panyam, Jayanth
    JOURNAL OF CONTROLLED RELEASE, 2010, 141 (02) : 137 - 144
  • [10] Trafficking of a Single Photosensitizing Molecule to Different Intracellular Organelles Demonstrates Effective Hydroxyl Radical-Mediated Photodynamic Therapy in the Endoplasmic Reticulum
    Gilson, Rebecca C.
    Tang, Rui
    Gautam, Krishna Sharmah
    Grabowska, Dorota
    Achilefu, Samuel
    BIOCONJUGATE CHEMISTRY, 2019, 30 (05) : 1451 - 1458