Foldamers as dynamic receptors: Probing the mechanism of molecular association between helical oligomers and rodlike ligands

被引：0
|
作者：
Tanatani, A
Hughes, TS
Moore, JS
机构：
[1] Univ Illinois, Dept Chem, Roger Adams Lab, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Mat Sci & Engn, Roger Adams Lab, Urbana, IL 61801 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 02期
关键词：
D O I：
10.1002/1521-3773(20020118)41:2<325::AID-ANIE325>3.0.CO;2-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A dynamic binding mechanism allows the association of dumbbell-shaped ligand 2 with helical folded oligo(m-phenyleneethynylene)s 1 (see schematic representation). Association constants are oligomer length specific, with a maximum value for the icosamer and docosamer. These oligomers have helical conformations that are highly shape-complementary to 1; shorter and longer oligomers exhibit association constants roughly an order of magnitude smaller.
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页码：325 / +
页数：5
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