Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

被引:90
|
作者
Sanwlani, Rahul [1 ]
Fonseka, Pamali [1 ]
Chitti, Sai, V [1 ]
Mathivanan, Suresh [1 ]
机构
[1] La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Bundoora, Vic 3083, Australia
基金
澳大利亚研究理事会;
关键词
exosomes; extracellular vesicle proteome; animal extracellular vesicles; milk extracellular vesicles; cellular crosstalk; cross-species communication; interindividual communication; extracellular vesicle-based therapy; drug delivery; HUMAN BREAST-MILK; HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-RELATED MICRORNAS; MESENCHYMAL STEM-CELLS; DOUBLE-STRANDED DNA; GROWTH-FACTOR-I; COW MILK; MEMBRANE-VESICLES; TRANSFERRIN RECEPTOR; EXOSOMAL FORMULATION;
D O I
10.3390/proteomes8020011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well characterized and are known to carry a diverse cargo of proteins, nucleic acids, lipids and other biomolecules. Milk-derived EVs have been demonstrated to survive harsh and degrading conditions in gut, taken up by various cell types, cross biological barriers and reach peripheral tissues. The cargo carried by these dietary EVs has been suggested to have a role in cell growth, development, immune modulation and regulation. Hence, there is considerable interest in understanding the role of milk-derived EVs in mediating inter-organismal and cross-species communication. Furthermore, various attributes such as it being a natural source, as well as its abundance, scalability, economic viability and lack of unwarranted immunologic reactions, has generated significant interest in deploying milk-derived EVs for clinical applications such as drug delivery and disease therapy. In this review, the role of milk-derived EVs in inter-organismal, cross-species communication and in drug delivery is discussed.
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页数:26
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