Hazard-based nonparametric survivor function estimation

被引:12
|
作者
Prentice, RL
Moodie, FZ
Wu, JR
机构
[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
[2] St Jude Childrens Res Hosp, Memphis, TN 38105 USA
关键词
bivariate hazard function; bivariate survivor function; censored data; nonparametric estimator; Peano series;
D O I
10.1046/j.1369-7412.2003.05182.x
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
A representation is developed that expresses the bivariate survivor function as a function of the hazard function for truncated failure time variables. This leads to a class of nonparametric survivor function estimators that avoid negative mass. The transformation from hazard function to survivor function is weakly continuous and compact differentiable, so that such properties as strong consistency, weak convergence to a Gaussian process and boot-strap applicability for a hazard function estimator are inherited by the corresponding survivor function estimator. The set of point mass assignments for a survivor function estimator is readily obtained by using a simple matrix calculation on the set of hazard rate estimators. Special cases arise from a simple empirical hazard rate estimator, and from an empirical hazard rate estimator following the redistribution of singly censored observations within strips. The latter is shown to equal van der Laan's repaired nonparametric maximum likelihood estimator, for which a Greenwood-like variance estimator is given. Simulation studies are presented to compare the moderate sample performance of various nonparametric survivor function estimators.
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页码:305 / 319
页数:15
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