Chronic IL1β Exposure Enhances Self-Renewal Ability and Myeloid Priming in TET2 Deficient Stem and Progenitor Cells

被引：0
|
作者：
McClatchy, John [1 ]
Strongantsev, Ruslan [1 ]
Wolfe, Emily [1 ]
Estabrook, Joseph [1 ]
Lin, Hsin-Yun [1 ]
Hosseini, Mona M. [1 ]
Mohamed, Hisham [1 ]
Agarwal, Anupriya [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Portland, OR 97201 USA
来源：
BLOOD | 2022年 / 140卷
关键词：
D O I：
10.1182/blood-2022-170565
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：8594 / 8595
页数：2
相关论文
共 50 条
  • [1] CHRONIC IL1B INDUCED STRESS DRIVES EXPANSION OF TET2 DEFICIENT PROGENITORS THROUGH ENHANCED SELF-RENEWAL ABILITY
    McClatchy, John
    Strogantsev, Ruslan
    Eden, Christopher
    Lin, Hsin-Yun
    Mohammadhosseini, Mona
    Monteblanco, Andrea
    Goldman, Devorah
    Cimmino, Luisa
    Fleming, William
    Mohammed, Hisham
    Agarwal, Anupriya
    EXPERIMENTAL HEMATOLOGY, 2021, 100 : S87 - S87
  • [2] Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
    Moran-Crusio, Kelly
    Reavie, Linsey
    Shih, Alan
    Abdel-Wahab, Omar
    Ndiaye-Lobry, Delphine
    Lobry, Camille
    Figueroa, Maria E.
    Vasanthakumar, Aparna
    Patel, Jay
    Zhao, Xinyang
    Perna, Fabiana
    Pandey, Suveg
    Madzo, Jozef
    Song, Chunxiao
    Dai, Qing
    He, Chuan
    Ibrahim, Sherif
    Beran, Miloslav
    Zavadil, Jiri
    Nimer, Stephen D.
    Melnick, Ari
    Godley, Lucy A.
    Aifantis, Iannis
    Levine, Ross L.
    CANCER CELL, 2011, 20 (01) : 11 - 24
  • [3] Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal
    Aljoufi, Arafat
    Zhang, Chi
    Ropa, James
    Chang, Wennan
    Palam, Lakshmi Reddy
    Cooper, Scott
    Ramdas, Baskar
    Capitano, Maegan L.
    Broxmeyer, Hal E.
    Kapur, Reuben
    BLOOD, 2022, 140 (11) : 1263 - 1277
  • [4] Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells
    Hiroyoshi Kunimoto
    Yumi Fukuchi
    Masatoshi Sakurai
    Ken Sadahira
    Yasuo Ikeda
    Shinichiro Okamoto
    Hideaki Nakajima
    Scientific Reports, 2
  • [5] Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells
    Kunimoto, Hiroyoshi
    Fukuchi, Yumi
    Sakurai, Masatoshi
    Sadahira, Ken
    Ikeda, Yasuo
    Okamoto, Shinichiro
    Nakajima, Hideaki
    SCIENTIFIC REPORTS, 2012, 2
  • [6] Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells
    McClatchy, J.
    Strogantsev, R.
    Wolfe, E.
    Lin, H. Y.
    Mohammadhosseini, M.
    Davis, B. A.
    Eden, C.
    Goldman, D.
    Fleming, W. H.
    Conley, P.
    Wu, G.
    Cimmino, L.
    Mohammed, H.
    Agarwal, A.
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [7] Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells
    J. McClatchy
    R. Strogantsev
    E. Wolfe
    H. Y. Lin
    M. Mohammadhosseini
    B. A. Davis
    C. Eden
    D. Goldman
    W. H. Fleming
    P. Conley
    G. Wu
    L. Cimmino
    H. Mohammed
    A. Agarwal
    Nature Communications, 14
  • [8] Disruption of Tet2 Leads to Enhanced Self-Renewal and Competitive Repopulating Capacity of Fetal Liver Hematopoietic Stem Cells
    Kunimoto, Hiroyoshi
    Fukuchi, Yumi
    Sakurai, Masatoshi
    Sadahira, Ken
    Ikeda, Yasuo
    Okamoto, Shinichiro
    Nakajima, Hideaki
    BLOOD, 2011, 118 (21) : 1009 - 1010
  • [9] Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
    Pietras, Eric M.
    Mirantes-Barbeito, Cristina
    Fong, Sarah
    Loeffler, Dirk
    Kovtonyuk, Larisa V.
    Zhang, SiYi
    Lakshminarasimhan, Ranjani
    Chin, Chih Peng
    Techner, Jose-Marc
    Will, Britta
    Nerlov, Claus
    Steidl, Ulrich
    Manz, Markus G.
    Schroeder, Timm
    Passegue, Emmanuelle
    NATURE CELL BIOLOGY, 2016, 18 (06) : 607 - +
  • [10] Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
    Eric M. Pietras
    Cristina Mirantes-Barbeito
    Sarah Fong
    Dirk Loeffler
    Larisa V. Kovtonyuk
    SiYi Zhang
    Ranjani Lakshminarasimhan
    Chih Peng Chin
    José-Marc Techner
    Britta Will
    Claus Nerlov
    Ulrich Steidl
    Markus G. Manz
    Timm Schroeder
    Emmanuelle Passegué
    Nature Cell Biology, 2016, 18 : 607 - 618
12345