Liquidambar orientalisMill. gum extract induces autophagy via PI3K/Akt/mTOR signaling pathway in prostate cancer cells

被引：13
|
作者：
Atmaca, Harika [1 ]
Pulat, Cisil Camli [2 ]
Cittan, Mustafa [3 ]
机构：
[1] Manisa Celal Bayar Univ, Fac Sci & Letters, Dept Biol, Sect Mol Biol, Muradiye, Manisa, Turkey
[2] Manisa Celal Bayar Univ, Appl Sci Res Ctr, Muradiye, Turkey
[3] Manisa Celal Bayar Univ, Fac Sci & Letters, Dept Chem, Sect Analyt Chem, Muradiye, Turkey
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH | 2022年 / 32卷 / 05期
关键词：
Liquidambar orientalisMill; cytotoxicity; autophagy; ravidomycin; PI3K; prostate cancer; TRADITIONAL MEDICINE; FOLK MEDICINE; APOPTOSIS; INDUCTION; TURKEY; DEATH; OILS;
D O I：
10.1080/09603123.2020.1818187
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Liquidambar orientalisMill . (LOM), is an endemic species having a local distribution in the southwestern coastal district of Turkey. Styrax liquidus gum (SLG), is a gum-like resinous which exudates in response to injury of the trunk of LOM. The aim of the study was to investigate the cytotoxic effects and the molecular mechanisms of the ethanolic SLG extract in human prostate cancer cells. GC-MS analysis was performed to identify the volatile compound composition. Cytotoxicity was determined by XTT analysis. Apoptosis and necrosis were evaluated via ELISA assay. Autophagic cell death was detected via monodansylcadaverine (MDC) staining and by measuring the levels of LC3I and LC3II. The protein levels of p-PI3K, p-Akt and p-mTOR were evaluated by western blot analysis. In the present study, it is shown that the SLG extract containing a considerable amount of ravidomycin derivate induced autophagic cell death in prostate cancer cells via inhibiting the PI3K/Akt/mTOR pathway.
引用
收藏
页码：1011 / 1019
页数：9
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