Encapsulation of Curcumin and Curcumin Derivative in Polymeric Nanospheres

被引：20
|
作者：
Sobh, R. A. [1 ]
Mohamed, W. S. [1 ]
Moustafa, A. B. [1 ]
Nasr, H. E. [1 ]
机构：
[1] Natl Res Ctr, Polymers & Pigments Dept, Cairo, Egypt
来源：
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2015年 / 54卷 / 14期
关键词：
Anti-cancer; Curcumin; Microemulsion; Nanospheres; IN-VITRO RELEASE; DIFFERENTIAL MICROEMULSION POLYMERIZATION; DRUG-DELIVERY; ANTICANCER ACTIVITY; PLGA NANOPARTICLES; MICROSPHERES; STABILITY; COPOLYMER; SYSTEM; CELLS;
D O I：
10.1080/03602559.2014.1003230
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Curcumin and curcumin derivative were loaded on biocompatible methyl methacrylate-hydroxyethyl methacrylate copolymeric nanospheres via in situ microemulsion polymerization. The effect of monomer composition and the emulsifier concentration on the entrapment efficiency, the particle size, and zeta potential of the drug loaded-polymeric nanospheres have been studied. The hydrophilic curcumin derivative was loaded with a high value which reached to about (92 +/- 0.5%) against (85 +/- 0.8%) recorded for the hydrophobic curcumin. In vitro release of curcumin and its derivative loaded in polymeric nanospheres showed slow and a sustained release pattern.
引用
收藏
页码：1457 / 1467
页数：11
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